Walter Chazin

The iron-binding siderophore enterobactin is required for the response of multi-drug resistant Klebsiella pneumoniae to zinc limitation

This study shows that enterobactin synthesis and uptake are essential for multi-drug resistant Klebsiella pneumoniae to grow under zinc limitation, independent of iron and Zur regulation.

The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair

This study investigates the role of XPG interactions with TFIIH subunits p62 and XPD in nucleotide excision repair, showing their importance for catalytic activity and incision initiation.

Exploring metalloproteome remodeling in calprotectin-stressed Acinetobacter baumannii using chemoproteomics

This study uses chemoproteomics to show that calprotectin stress in Acinetobacter baumannii leads to undermetalation of metalloproteomes, impairing key metabolic and cellular processes.

RAD52 and RPA act in a concert promoting inverse RNA strand exchange

The paper investigates how RAD52 and RPA interact to promote inverse RNA strand exchange in DNA repair using NMR and biochemical methods.

5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells

This study shows that 5hmC increases PARP1 trapping on chromatin in olaparib-treated cells, restoring PARP inhibitor sensitivity in BRCA1/2-deficient cancer cells.

Microbial biosensor for sensing and treatment of intestinal inflammation

The paper optimizes a microbial biosensor to detect and respond to the clinically relevant intestinal inflammation biomarker calprotectin.

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

The paper identifies RADX separation of function mutants using CRISPR base editing screens, showing reduced RAD51 ATP hydrolysis activity and replication defects.