The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine
Michael W. Crawford, Walid Abdelwahab, Karthik Siram, Christopher J. Parkins, Henry F. Harrison, E. Taylor Stone, Samantha R. Osman, Dillon Schweitzer, David J. Burkhart, Amelia K. Pinto, James D. Brien, Jessica Louise Smith, Alec J. Hirsch
This paper develops a Powassan virus-like-particle (POW-VLP) vaccine adjuvanted with INI-4001, showing it enhances immunogenicity, reduces viral burden, and provides full protection in mice.
npj Vaccines · Jul 16, 2025Peer-reviewedImmunology