Author

Karthik Siram

University of MontanaORCID 0000-0002-7669-3945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

David J. BurkhartiD· 2 shared Alec J. HirschiD· 1 shared Amelia K. PintoiD· 1 shared Borries DemeleriD· 1 shared Brooke K. HoppeiD· 1 shared Christopher J. Parkins· 1 shared Daihyun SongiD· 1 shared Dillon Schweitzer· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

David J. BurkhartORCID

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2 papers

Recent·Most cited

The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine

Michael W. Crawford, Walid Abdelwahab, Karthik Siram, Christopher J. Parkins, Henry F. Harrison, E. Taylor Stone, Samantha R. Osman, Dillon Schweitzer, David J. Burkhart, Amelia K. Pinto, James D. Brien, Jessica Louise Smith, Alec J. Hirsch

This paper develops a Powassan virus-like-particle (POW-VLP) vaccine adjuvanted with INI-4001, showing it enhances immunogenicity, reduces viral burden, and provides full protection in mice.

npj Vaccines · Jul 16, 2025Peer-reviewedImmunology

A cationic liposome-formulated Toll Like Receptor (TLR)7/8 agonist enhances the efficacy of a vaccine against fentanyl toxicity

Fatima Alamin Awad Alkareem Hamid, Nguyet‐Minh Nguyen Le, Daihyun Song, Hardik Hastibhai Amin, Linda D. Hicks, Sophia Bird, Karthik Siram, Brooke K. Hoppe, Borries Demeler, Jay T. Evans, David J. Burkhart, Marco Pravetoni

This paper shows that cationic liposome-formulated TLR7/8 agonist enhances fentanyl vaccine efficacy by improving immune activation and protecting against fentanyl-induced toxicity in rats.

Journal of Controlled Release · May 27, 2025Peer-reviewedImmunology