Author

Jessica Louise Smith

Oregon National Primate Research CenterORCID 0000-0002-2381-861XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Alec J. HirschiD· 3 shared Amelia K. PintoiD· 1 shared Anand G. ValaiD· 1 shared Ava M. VargasoniD· 1 shared C.H. ArrowsmithiD· 1 shared Christopher J. Parkins· 1 shared Chun‐Hsing CheniD· 1 shared Corinne E. Augelli‐SzafraniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

Alec J. HirschORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 30, 2026

A broadly active flavivirus NS4B targeting compound that blocks NS4B-NS3 binding and replication organelle formation

Jessica Louise Smith, Theresa Hoang-Anh Nguyen, Sixue Zhang…·Alec J. Hirsch

This paper identifies SRI-38841, a xanthine analog that inhibits multiple flaviviruses by blocking NS4B-NS3 interaction and replication organelle formation.

DOI 10.64898/2026.10.29.762806

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Pharmacology & ToxicologyACS Infectious DiseasesPeer-reviewedJul 18, 2025

An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

M. Bose, Hans J. Oh, John D. Sears…·Timothy Mark Willson

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

7 citationstop 3%

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Immunologynpj VaccinesPeer-reviewedJul 16, 2025

The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine

Michael W. Crawford, Walid Abdelwahab, Karthik Siram…·Alec J. Hirsch

This paper develops a Powassan virus-like-particle (POW-VLP) vaccine adjuvanted with INI-4001, showing it enhances immunogenicity, reduces viral burden, and provides full protection in mice.

7 citationstop 4%

mouseexperimental assay

𝕏 PostBluesky