Christopher J. Parkins

The human cytomegalovirus chemokine binding protein UL22A is necessary for efficient reactivation from latency in CD34+ hematopoietic progenitor cells.

This paper shows that HCMV's UL22A protein is essential for reactivation from latency in CD34+ hematopoietic progenitor cells, with tyrosine residues critical for this process, but RANTES neutralization does not fully restore reactivation.

HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36

This study shows HCMV uses UL8 and miR-UL36 to suppress Notch signaling, promoting reactivation in CD34+ hematopoietic progenitor cells.

A Zika Virus-Like Particle Vaccine Mitigates Early Pregnancy Loss In Rhesus Macaques

This study evaluates a Zika virus-like particle (VLP) vaccine in rhesus macaques, showing it reduces early pregnancy loss caused by a highly pathogenic ZIKV strain.

The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine

This paper develops a Powassan virus-like-particle (POW-VLP) vaccine adjuvanted with INI-4001, showing it enhances immunogenicity, reduces viral burden, and provides full protection in mice.

Viral and host network analysis of the human cytomegalovirus transcriptome in latency.

The paper analyzes the transcriptional network of HCMV in latency by comparing gene expression with and without UL135 and UL138, revealing their roles in viral gene regulation and hematopoietic differentiation.

Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice

This study shows that HCMV miRNAs downregulate Akt to promote reactivation from latency in CD34+ cells and humanized mice.