Author

Alec J. Hirsch

Oregon Health & Science UniversityORCID 0000-0002-8613-0740Unclaimed ORCID profile · follow to get notified of new preprints

Activity by Year

2024-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

Jessica Louise SmithORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A broadly active flavivirus NS4B targeting compound that blocks NS4B-NS3 binding and replication organelle formation

Jessica Louise Smith, Theresa Hoang-Anh Nguyen, Sixue Zhang, Omar Moukha‐Chafiq, Corinne E. Augelli‐Szafran, Alec J. Hirsch

This paper identifies SRI-38841, a xanthine analog that inhibits multiple flaviviruses by blocking NS4B-NS3 interaction and replication organelle formation.

bioRxiv · Oct 30, 2026 · PreprintMicrobiology

A Zika Virus-Like Particle Vaccine Mitigates Early Pregnancy Loss In Rhesus Macaques

Hannah K. Jaeger, Jessica R. Smith, Caralyn S. Labriola, Lydia J. Pung, Olivia L. Hagen, Michael C. Denton, Rahul J. D'Mello, Christopher J. Parkins, Whitney C. Weber, Samuel Medica, Craig N. Kreklywich, Victor R. DeFilippis, Stephen Bondoc, Kathleen Busman‐Sahay, Jenna N. Castro, , Alec J. Hirsch

This study evaluates a Zika virus-like particle (VLP) vaccine in rhesus macaques, showing it reduces early pregnancy loss caused by a highly pathogenic ZIKV strain.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology

Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates

Kristin A. D. Sauter, Gabriela M. Webb, Lindsay Bader, Craig N. Kreklywich, Diana Lynn Takahashi, Cicely Zaro, Casey M. McGuire, Anne D. Lewis, Lois M. A. Colgin, Melissa Ann Kirigiti, Hannah Blomenkamp, Cleiton T. Pessoa, Matthew C. Humkey, Jesse Hulahan, Madeleine Sleeman, , Charles T. Roberts

This study investigates how obesity affects the long-term effects of SARS-CoV-2 infection in nonhuman primates, finding persistent changes in multiple parameters in most animals.

PLoS Pathogens · Jul 24, 2025Peer-reviewedPathology

An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

M. Bose, Hans J. Oh, John D. Sears, Chun‐Hsing Chen, Anand G. Vala, Shubin Liu, Kacey Marie Talbot, Mohammad Anwar Hossain, Peter J. Brown, Scott Houliston, Julia Garcia Perez, Fengling Li, Meareg Amare, Peter Halfmann, Jessica Louise Smith, , Timothy Mark Willson

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

ACS Infectious Diseases · Jul 18, 2025Peer-reviewedPharmacology & Toxicology

The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine

Michael W. Crawford, Walid Abdelwahab, Karthik Siram, Christopher J. Parkins, Henry F. Harrison, E. Taylor Stone, Samantha R. Osman, Dillon Schweitzer, David J. Burkhart, Amelia K. Pinto, James D. Brien, Jessica Louise Smith, Alec J. Hirsch

This paper develops a Powassan virus-like-particle (POW-VLP) vaccine adjuvanted with INI-4001, showing it enhances immunogenicity, reduces viral burden, and provides full protection in mice.

npj Vaccines · Jul 16, 2025Peer-reviewedImmunology

Systemic exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the living mouse brain

Aniruddha Das, Jacob Icardi, Julie A. Borovicka, Sarah J. Holden, Henry F. Harrison, Alec J. Hirsch, Jacob Raber, Hod Dana

This study shows that systemic exposure to SARS-CoV-2 virus-like particles disrupts cortical neuronal activity in mice, with persistent effects and heightened vulnerability in htau mice.

bioRxiv · Nov 26, 2024 · PreprintNeuroscience