Membrane Tension Drives Opening of NINJ1 Lesions in Dying Cells
Ella Hartenian, Elliott M. Bernard, Giulia E. M. Ammirati, Hubert B. Leloup, Stefania Anna Mari, Morris Degen, Magalie Agustoni, José Carlos Santos, Ivo M. Glück, Gonzalo Cebrero, Mirko Stauffer, Jonne H. Helenius, Dimitrios Fotiadis, Camilo Pérez, Christian Sieben, , Petr Brož
This study shows membrane tension drives NINJ1 filament opening, causing cell lysis, and explains why NINJ2 fails to form lesions.
bioRxiv · Oct 29, 2024 · PreprintImmunology