In-situ structures of the Legionella Dot/Icm T4SS identify the DotA-IcmX complex as the gatekeeper for effector translocation
Jian Yue, Samira Heydari, Donghyun Park, David Chetrit, Shoichi Tachiyama, Wangbiao Guo, Jack M. Botting, Shenping Wu, Craig R. Roy, Jun Liu
This study uses cryo-electron microscopy to reveal the structure of the Dot/Icm T4SS in Legionella pneumophila, identifying the DotA-IcmX complex as the gatekeeper for effector translocation.
Proceedings of the National Academy of Sciences · Sep 23, 2025Peer-reviewedMolecular Biology