Jack M. Botting

This study determines the near-atomic structure of Vibrio cholerae's sheathed flagellum and reveals its dynamic architecture and membrane-coupled mechanisms.

This study determines the asymmetric structure of Treponema denticola flagella and shows how it enables efficient motility.

This paper identifies FlcE as a flagellar collar protein in Borrelia burgdorferi that stabilizes the FliL-stator complex, enhancing motility and torque generation.

This study uses cryo-EM to determine the structure of the flagellar export apparatus in Borrelia burgdorferi, revealing its assembly mechanism and role in substrate translocation.

This paper uses FIB-SEM and machine learning to study Coxiella burnetii infection, revealing 3D structure variations in bacteria and CCVs and showing that a mutant's vacuole defect does not affect its developmental cycle.

This study determines the near-atomic structure of H. pylori sheathed flagella using cryo-EM, revealing how flagellins and glycans contribute to filament stability and motility.

This study uses cryo-electron microscopy to reveal the structure of the Dot/Icm T4SS in Legionella pneumophila, identifying the DotA-IcmX complex as the gatekeeper for effector translocation.

This study builds a near-complete model of the complex flagellar motor in Campylobacter jejuni, revealing its architecture, composition, and evolutionary origins.

This study identifies two distinct Type IV pili in Saccharibacteria, showing their roles in host binding, competition, and motility.