Wangbiao Guo

This study reveals how asymmetric FlaA sheath assembly in Borreliella burgdorferi flagella influences morphology and motility through structural and genetic analyses.

The paper identifies a molecular clutch mechanism in Borrelia burgdorferi flagellar motors that controls stator engagement and torque generation through distinct conformational states.

This study uses in situ cryo-EM to reveal how the flagellar motor in Borrelia burgdorferi transmits high torque through mechanical coupling and a split washer-shaped FrbA brace.

This study determines the near-atomic structure of Vibrio cholerae's sheathed flagellum and reveals its dynamic architecture and membrane-coupled mechanisms.

This study determines the asymmetric structure of Treponema denticola flagella and shows how it enables efficient motility.

This paper identifies FlcE as a flagellar collar protein in Borrelia burgdorferi that stabilizes the FliL-stator complex, enhancing motility and torque generation.

This study uses cryo-EM to determine the structure of the flagellar export apparatus in Borrelia burgdorferi, revealing its assembly mechanism and role in substrate translocation.

This paper identifies FlhG, a MinD-like ATPase, as a spatial regulator coupling flagellar assembly to cytokinesis in Borrelia burgdorferi, revealing how spirochetes coordinate flagellation with cell division.

This study determines the near-atomic structure of H. pylori sheathed flagella using cryo-EM, revealing how flagellins and glycans contribute to filament stability and motility.

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.

The paper proposes the Texas 2-Step model to explain how YcgR modulates flagellar motor rotation in E. coli by interacting with MotA and FliG through conformational changes.

This study uses cryo-electron microscopy to reveal the structure of the Dot/Icm T4SS in Legionella pneumophila, identifying the DotA-IcmX complex as the gatekeeper for effector translocation.