Jun Liu

This study identifies FapA as a cytoplasmic component of the H. pylori flagellar cage that links the flagellar structure to surface-associated behaviors like biofilm formation.

This study uses cryo-EM to reveal the structural dynamics and activation mechanism of the Legionella Dot/Icm T4SS, showing how it transitions from a resting state to an active secretion machine.

This study reveals how asymmetric FlaA sheath assembly in Borreliella burgdorferi flagella influences morphology and motility through structural and genetic analyses.

The paper identifies a molecular clutch mechanism in Borrelia burgdorferi flagellar motors that controls stator engagement and torque generation through distinct conformational states.

This study uses in situ cryo-EM to reveal how the flagellar motor in Borrelia burgdorferi transmits high torque through mechanical coupling and a split washer-shaped FrbA brace.

This paper models the Shigella T3SS pod complex using AlphaFold, showing two Spa33 proteins bind MxiK and SPOA2-SPOA2 domains, supporting a 1:4:2 stoichiometry and explaining electron density data.

The paper determines the in vivo structures of P22 infection intermediates and explains how gp10 templates the sequential assembly of three proteins into a trans-envelope channel for genome translocation.

This study uses cryo-EM and computational methods to model the structure of HPV16 L2 protein within the capsid, revealing its conformational flexibility and positioning for virus entry.

This study determines the near-atomic structure of Vibrio cholerae's sheathed flagellum and reveals its dynamic architecture and membrane-coupled mechanisms.

The paper shows lipid imbalance creates Golgi whorls that sequester small GTPases, disrupting trafficking and viability.

This study determines the structure of Vibrio phage Peru-2, revealing its multimodal adsorption strategy and infection mechanism involving tailspikes and interactions with bacterial surfaces.

This study determines the asymmetric structure of Treponema denticola flagella and shows how it enables efficient motility.

This paper identifies FlcE as a flagellar collar protein in Borrelia burgdorferi that stabilizes the FliL-stator complex, enhancing motility and torque generation.

This study uses cryo-EM to determine the structure of the flagellar export apparatus in Borrelia burgdorferi, revealing its assembly mechanism and role in substrate translocation.

This paper shows that cAMP inputs into a bistable regulatory network drive subpopulations of Pseudomonas aeruginosa cells to prime for T3SS expression.

This paper uses FIB-SEM and machine learning to study Coxiella burnetii infection, revealing 3D structure variations in bacteria and CCVs and showing that a mutant's vacuole defect does not affect its developmental cycle.

This paper identifies FlhG, a MinD-like ATPase, as a spatial regulator coupling flagellar assembly to cytokinesis in Borrelia burgdorferi, revealing how spirochetes coordinate flagellation with cell division.

The paper describes a protein fold switch in a bactericidal nanomachine that enables membrane puncture and bactericidal activity.

This study determines the near-atomic structure of H. pylori sheathed flagella using cryo-EM, revealing how flagellins and glycans contribute to filament stability and motility.

The paper develops a DNA nanodevice to apply controlled forces to proteins, demonstrating its use in studying mechanosensitive protein interactions and identifying novel tension-dependent binders.

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.

This study uses cryo-electron microscopy to reveal the structure of the Dot/Icm T4SS in Legionella pneumophila, identifying the DotA-IcmX complex as the gatekeeper for effector translocation.

This study investigates OMT formation in F. novicida using cryo-ET and microscopy, revealing envelope modifications and links to type VI secretion and phagosomal membrane changes.

This study identifies the regulatory mechanisms of BbHtrA in Borrelia burgdorferi, showing its critical roles in motility, stress response, and virulence gene expression.

This study builds a near-complete model of the complex flagellar motor in Campylobacter jejuni, revealing its architecture, composition, and evolutionary origins.

This study identifies two distinct Type IV pili in Saccharibacteria, showing their roles in host binding, competition, and motility.

This study identifies FlgV as a conserved flagellar component in Borrelia burgdorferi, showing its role in flagellar assembly and pathogen dissemination in mice.

This study uses cryo-electron tomography to show that spatial restrictions in axons and presynaptic varicosities influence mitochondrial morphology and membrane organization.

The paper uses cryo-electron tomography and mutagenesis to study the fT3SS machine in Borrelia burgdorferi, revealing a distinct cytosolic ATPase complex linked to the flagellar C-ring.