RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling
Andy Nelson, Thomas J. Turbyville, Srisathiyanarayanan Dharmaiah, Megan Rigby, Rendong Yang, John Columbus, Robert M. Stephens, Drew Sciacca, Getiria Onsongo, Anne E. Sarver, Subbaya Subramanian, Dwight V. Nissley, Dhirendra K. Simanshu, Emil Lou
The paper identifies a novel NRAS internal tandem duplication in colorectal cancer that disrupts GAP-binding, leading to sustained RAS activation and oncogenic signaling.
bioRxiv · Aug 15, 2019 · PreprintMolecular Biology