Molecular BiologybioRxivPreprint
RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling
Andy Nelson, Thomas J. Turbyville, Srisathiyanarayanan Dharmaiah…·Emil Lou
The paper identifies a novel NRAS internal tandem duplication in colorectal cancer that disrupts GAP-binding, leading to sustained RAS activation and oncogenic signaling.
DOI 10.1101/737098