Author
Thomas J. Turbyville
Frederick National Laboratory for Cancer ResearchORCID 0000-0003-2638-9520Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2025 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 19 mutual co-author links4 papers
Recent·Most cited
- BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving the Disassembly of the Autoinhibited BRAF State
Daniel A. Ritt, David Durrant, Matthew R. Drew…·Deborah K. Morrison
This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.
9 citations - BioinformaticsCell SystemsPeer-reviewed
Virtual screening for small molecule pathway regulators by image profile matching
Mohammad Hossein Rohban, Ashley M. Fuller, Ceryl Tan…·Anne Elizabeth Carpenter
The paper identifies small molecule regulators of biological pathways by matching compound effects to known pathway phenotypes in public cell image data.
- Molecular BiologybioRxivPreprint
RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling
Andy Nelson, Thomas J. Turbyville, Srisathiyanarayanan Dharmaiah…·Emil Lou
The paper identifies a novel NRAS internal tandem duplication in colorectal cancer that disrupts GAP-binding, leading to sustained RAS activation and oncogenic signaling.
DOI 10.1101/737098