Author

Dhirendra K. Simanshu

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-9717-4618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Dwight V. NissleyiD· 2 shared Srisathiyanarayanan DharmaiahiD· 2 shared Andrew G. StepheniD· 1 shared Andrew J. AguirreiD· 1 shared Andrew Lee HongiD· 1 shared Andrew O. GiacomelliiD· 1 shared Andy NelsoniD· 1 shared Anne E. SarveriD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Dwight V. NissleyORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 22, 2024

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

Jason J. Kwon, Julien Dilly, Shengwu Liu…·Andrew J. Aguirre

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

13 citations

humanproteomics

Molecular BiologybioRxivPreprintAug 15, 2019

RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling

Andy Nelson, Thomas J. Turbyville, Srisathiyanarayanan Dharmaiah…·Emil Lou

The paper identifies a novel NRAS internal tandem duplication in colorectal cancer that disrupts GAP-binding, leading to sustained RAS activation and oncogenic signaling.

DOI 10.1101/737098

humanwhole-exome sequencing