Emil Lou

Explaining and predicting pseudoprogression in immunotherapythrough joint modeling of immune infiltration and ctDNA dynamics

This paper develops a mathematical model of tumor-immune dynamics under ICI therapy to predict pseudoprogression and trains a classifier using tumor and ctDNA data to improve progression classification.

Modeling CISH-KO TIL therapy: T-cell persistence and endogenous competition determine response in gastrointestinal cancer

This study models CISH-KO TIL therapy in gastrointestinal cancer, finding that T-cell persistence and endogenous competition are key determinants of treatment response.

Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis

This study shows that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis in colorectal cancer, and inhibiting NET formation reduces necrosis and improves chemotherapy outcomes.

CISH, a novel intracellular immune checkpoint, in comparison and combination to existing and emerging cancer immune checkpoints

This study shows that deleting CISH enhances T cell anti-cancer functions more than other intracellular checkpoints, improving tumor antigen recognition and killing in CAR-T cells.

Early ctDNA kinetics as a dynamic biomarker of cancer treatment response

This study develops a framework to design ctDNA biomarkers for cancer treatment response by modeling ctDNA kinetics and simulating virtual patient cohorts.

RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling

The paper identifies a novel NRAS internal tandem duplication in colorectal cancer that disrupts GAP-binding, leading to sustained RAS activation and oncogenic signaling.