Author

John Columbus

Frederick National Laboratory for Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1 Assay:metabolomics· 1

Frequent Co-Authors

Thomas J. TurbyvilleiD· 2 shared Andy NelsoniD· 1 shared Anne E. SarveriD· 1 shared Antonis E. KoromilasiD· 1 shared Atsuo T. SasakiiD· 1 shared Brajendra K. TripathiiD· 1 shared Carlos R. Azpilcueta‐NicolasiD· 1 shared Christopher B. MarshalliD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Thomas J. TurbyvilleORCID

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2 papers

Recent·Most cited

eIF2B Selectively Anchors and Activates Mutant KRAS

Hyungdong Kim, Shiqi Diao, Kwang‐Jin Cho, Hyun-Ro Lee, Junchen Liu, Pascal F. Egea, Tatu Pantsar, Milla Kurki, Nour Ghaddar, Shuo Wang, Jia Yi Zou, Mehdi Amiri, Ritchel B. Gannaban, John F. Hancock, Kylie M. Rice, , Antonis E. Koromilas

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

bioRxiv · Nov 10, 2025 · PreprintCancer Biology

RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling

Andy Nelson, Thomas J. Turbyville, Srisathiyanarayanan Dharmaiah, Megan Rigby, Rendong Yang, John Columbus, Robert M. Stephens, Drew Sciacca, Getiria Onsongo, Anne E. Sarver, Subbaya Subramanian, Dwight V. Nissley, Dhirendra K. Simanshu, Emil Lou

The paper identifies a novel NRAS internal tandem duplication in colorectal cancer that disrupts GAP-binding, leading to sustained RAS activation and oncogenic signaling.

bioRxiv · Aug 15, 2019 · PreprintMolecular Biology