Author

Dwight H. Kono

KU Leuven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1

Frequent Co-Authors

Caroline de Ocampo· 3 shared Jessica MayeuxiD· 3 shared K. Michael PollardiD· 3 shared Lisa JansseniD· 3 shared Peter HoetiD· 2 shared Amy K. Peiss· 1 shared Anant GharpureiD· 1 shared Andrew B. WardiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

Caroline de Ocampo

Mutual co-authors in cluster

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4 papers

Recent·Most cited

IPO9 modulates histone-dependent inhibition of cGAS activity

Ariana Sulpizio, Anant Gharpure, Emily N. Chin, David Lapointe, Francisco Martínez‐Peña, Jared T. Gillen Miller, Rosana González‐Quintial, Brett Bookser, Stephan Spangenberg, Daisuke Ogasawara, Stephan H. Spangenberg, Dwight H. Kono, Andrew B. Ward, Luke L. Lairson

The paper identifies IPO9 as a regulator of cGAS-STING signaling by releasing cGAS from H2A-H2B dimer inhibition, revealing structural insights into this mechanism.

bioRxiv · Aug 25, 2026 · PreprintImmunology

Silica-mediated exacerbation of inflammatory arthritis: A novel murine model

Lisa Janssen, Caroline de Ocampo, Dwight H. Kono, Steven Ronsmans, Manosij Ghosh, Peter Hoet, K. Michael Pollard, Jessica Mayeux

This paper develops a novel murine model of silica-induced inflammatory arthritis by exposing arthritis-prone mice to crystalline silica, showing it induces arthritis and autoimmunity while DR4-Tg mice are resistant.

Particle and Fibre Toxicology · Feb 9, 2026Peer-reviewedImmunology

Crystalline silica exposure induces multiple systemic autoimmune phenotypes including inflammatory arthritis and nephritis in Collaborative Cross mice with differing sub-clinical autoimmune profiles.

Lisa Janssen, Caroline de Ocampo, Dwight H. Kono, Peter Hoet, K. Michael Pollard, Jessica Mayeux

This study shows that silica exposure causes autoimmune diseases in mice with pre-existing subclinical autoimmunity, leading to more severe outcomes like arthritis and nephritis.

bioRxiv · May 22, 2025 · PreprintImmunology

Effect of Age on Xenobiotic-Induced Autoimmunity

Caroline de Ocampo, Amy K. Peiss, Ho Yeung Leung, Lisa Janssen, Dwight H. Kono, Jessica Mayeux, K. Michael Pollard

This study shows that aging increases spontaneous autoimmunity but reduces xenobiotic-induced autoimmunity in mice, with some older mice still showing a diminished response.

bioRxiv · May 22, 2025 · PreprintImmunology