K. Michael Pollard

Silica-mediated exacerbation of inflammatory arthritis: A novel murine model

This paper develops a novel murine model of silica-induced inflammatory arthritis by exposing arthritis-prone mice to crystalline silica, showing it induces arthritis and autoimmunity while DR4-Tg mice are resistant.

Crystalline silica exposure induces multiple systemic autoimmune phenotypes including inflammatory arthritis and nephritis in Collaborative Cross mice with differing sub-clinical autoimmune profiles.

This study shows that silica exposure causes autoimmune diseases in mice with pre-existing subclinical autoimmunity, leading to more severe outcomes like arthritis and nephritis.

Effect of Age on Xenobiotic-Induced Autoimmunity

This study shows that aging increases spontaneous autoimmunity but reduces xenobiotic-induced autoimmunity in mice, with some older mice still showing a diminished response.

Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes

This study identifies 37 QTL for facial shape in DO mice, finding enrichment for genes involved in skeletal and facial development, despite small individual effects.