Daisuke Ogasawara

Targeting proteasome composition reprograms tumor-intrinsic inflammation through selective degradation of STAT1

This study identifies a small molecule targeting PSME4, which stabilizes STAT1 and reprograms tumor inflammation, suppressing tumor growth by altering cytokine signaling.

IPO9 modulates histone-dependent inhibition of cGAS activity

The paper identifies IPO9 as a regulator of cGAS-STING signaling by releasing cGAS from H2A-H2B dimer inhibition, revealing structural insights into this mechanism.

Erucamide regulates retinal neurovascular crosstalk

This study identifies erucamide as a key regulator of retinal neurovascular crosstalk, showing its role in stabilizing retinal degeneration through TMEM19-mediated activation of myeloid cells.

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication

Assigning functionality to cysteines by base editing of cancer dependency genes

The paper uses base editing to assess the functional impact of cysteine mutations in cancer dependency genes, identifying essential and ligandable cysteines for drug development.