IPO9 modulates histone-dependent inhibition of cGAS activity
Ariana Sulpizio, Anant Gharpure, Emily N. Chin, David Lapointe, Francisco Martínez‐Peña, Jared T. Gillen Miller, Rosana González‐Quintial, Brett Bookser, Stephan Spangenberg, Daisuke Ogasawara, Stephan H. Spangenberg, Dwight H. Kono, Andrew B. Ward, Luke L. Lairson
The paper identifies IPO9 as a regulator of cGAS-STING signaling by releasing cGAS from H2A-H2B dimer inhibition, revealing structural insights into this mechanism.
bioRxiv · Aug 25, 2026 · PreprintImmunology