E. A. Miao

Caspase-1 and -11 defend against environmental but not host-adapted pathogens in genetically complex mice

This study shows that caspase-1 and -11 protect against environmental pathogens but not host-adapted ones in genetically diverse mice.

Chemokine expression profile of an innate granuloma

The paper uses spatial transcriptomics to study chemokine expression in granulomas formed by Chromobacterium violaceum infection, showing that CCR2 is critical for macrophage organization and bacterial containment.

Caspase-1 activates gasdermin A in non-mammals

The paper shows that caspase-1 activates GSDMA in non-mammals like amphibians, reptiles, and birds, revealing an evolutionary shift in caspase-1's target gasdermin.

Apoptotic signaling clears engineered Salmonella in an organ-specific manner

This study shows that apoptosis and pyroptosis clear engineered Salmonella from different organs in mice, with pyroptosis being more effective in myeloid niches and apoptosis in the intestinal niche.

An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2

This study identifies a novel granuloma model in mice induced by Chromobacterium violaceum, showing that innate immune mechanisms can eradicate an environmental pathogen without adaptive immunity.

AIM2 inflammasome activation in astrocytes occurs during the late phase of EAE

This study identifies AIM2 inflammasome activation in astrocytes during the late phase of EAE, distinct from traditional inflammasome-mediated inflammation.