Mechanical regulation of cell fate transitions underlying colorectal cancer metastasis formation
M. C. van der Net, M. J. Vliem, L. J. S. Kemp, C. Perez-Gonzalez, E. A. Strating, A. Krotenberg-Garcia, R. M. Houtekamer, K. B. van den Anker, J. L. Monster, H. J. G. Snippert, A. A. Khalil, J. van Rheenen, S. J. Suijkerbuijk, O. Kranenburg, D. Matic Vignjevic, M. Gloerich
This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.
bioRxiv · Sep 17, 2023 · PreprintCancer Biology