Author

W. C. Wimley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

E. B. Pasquale· 2 shared K. Hristova· 2 shared S. Guha· 2 shared A. Soldano· 1 shared B. J. Nelson· 1 shared C. Chen· 1 shared C. G. Starr· 1 shared C. H. Chen· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

E. B. Pasquale

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Author profile →

4 papers

Recent·Most cited

Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteria.

J. Ghimire, R. J. Hart, A. Soldano, C. Chen, S. Guha, J. P. Hoffmann, K. Hall, L. Sun, B. J. Nelson, T. K. Lu, J. K. Kolls, M. Rivera, L. A. Morici, W. C. Wimley

This study optimizes antimicrobial peptides to enhance activity against drug-resistant bacteria and biofilms while reducing cytotoxicity.

bioRxiv · Dec 1, 2022Biochemistry

The efficacy of EphA2 tyrosine phosphorylation increases with EphA2 oligomer size

E. Zapata-Mercado, G. Biener, D. McKenzie, W. C. Wimley, E. B. Pasquale, V. Raicu, K. Hristova

This study investigates the relationship between EphA2 oligomer size and signaling efficacy, finding a correlation between mean oligomer size and tyrosine phosphorylation.

bioRxiv · Jun 7, 2022 · PreprintBiophysics

Plasticity of transmembrane helix interactions in EphA2 dimers and oligomers

D. Wirth, E. Ozdemir, W. C. Wimley, E. B. Pasquale, K. Hristova

The paper investigates how EphA2 transmembrane helix mutations affect receptor-receptor interactions using FRET and FIF, finding plasticity in dimer interfaces rather than a binary switch between active/inactive states.

bioRxiv · Jun 6, 2022 · PreprintBiophysics

Rational tuning of a membrane-perforating antimicrobial peptide to selectively target membranes of different lipid composition

C. H. Chen, C. G. Starr, S. Guha, W. C. Wimley, M. B. Ulmschneider, J. Ulmschneider

This paper tunes an antimicrobial peptide to selectively target membranes of different lipid compositions using high-throughput screening and molecular dynamics simulations.

bioRxiv · Nov 1, 2020Biochemistry