Author

E. Bakkeren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

W.-D. Hardt· 5 shared M. Diard· 4 shared J. S. Huisman· 3 shared A. Egli· 2 shared E. Gul· 2 shared J. A. Herter· 2 shared S. Bonhoeffer· 2 shared Y. Steiger· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersMicrobiology

W.-D. Hardt

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Author profile →

5 papers

Recent·Most cited

The mobilizable plasmid P3 of Salmonella enterica serovar Typhimurium SL1344 depends on the P2 plasmid for conjugative transfer into a broad range of bacteria in vitro and in vivo

M. S. Gaissmaier, L. Laganenka, M. K.-M. Herzog, E. Bakkeren, W.-D. Hardt

bioRxiv · Sep 15, 2022Microbiology

A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

M. Diard, E. Bakkeren, D. Hoces, V. Lentsch, M. Arnoldini, F. Boehi, K. Schumann-Moor, J. Adamcik, L. Piccoli, A. Lanzavecchia, B. Stadtmueller, N. Donohue, M. Vanderwoude, P. Viollier, L. Falquet, , E. Slack

This paper shows that an oral vaccine inducing IgA in mice can direct Salmonella to evolve into less virulent variants with shorter O-antigens.

bioRxiv · May 13, 2021Immunology

Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

E. Bakkeren, J. A. Herter, J. S. Huisman, Y. Steiger, E. Gul, J. P. M. Newson, A. O. Brachmann, J. Piel, R. R. Regoes, S. Bonhoeffer, M. Diard, W.-D. Hardt

This study shows that plasmid dissemination in the gut is enhanced by antibiotic degradation in the lumen and cycling between gut and tissue reservoirs in Salmonella Typhimurium.

bioRxiv · Apr 8, 2021Evolutionary Biology

Cooperative virulence can emerge via horizontal gene transfer but is stabilized by transmission

E. Bakkeren, E. Gul, J. S. Huisman, Y. Steiger, A. Rocker, W.-D. Hardt, M. Diard

This study shows that horizontal gene transfer can enable virulence in Salmonella Typhimurium, but cooperative virulence is stabilized by transmission dynamics and population bottlenecks.

bioRxiv · Feb 11, 2021 · PreprintEvolutionary Biology

Clinical extended-spectrum beta-lactamase antibiotic resistance plasmids have diverse transfer rates and can spread in the absence of antibiotic selection

F. Benz, J. S. Huisman, E. Bakkeren, J. A. Herter, T. Stadler, M. Ackermann, M. Diard, A. Egli, A. R. Hall, W.-D. Hardt, S. Bonhoeffer

This study quantifies the conjugative transfer dynamics of ESBL plasmids in vitro and in vivo, showing variation in transfer efficiency and potential for predicting plasmid spread.

bioRxiv · Mar 3, 2020Microbiology