Author

D. Hoces

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. Slack· 5 shared C. Moresi· 3 shared M. Arnoldini· 3 shared W.-D. Hardt· 3 shared C. Loverdo· 2 shared E. Cappio Barazzone· 2 shared S. Berent· 2 shared V. Lentsch· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersImmunology

E. Slack

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A rationally designed inactivated Salmonella Typhimurium vaccine induces strong and long-lasting immune responses in pigs

V. Lentsch, S. Aslani, T. Echtermann, S. Preet, E. Cappio Barazzone, D. Hoces, C. Moresi, D. Kuemmerlen, E. Slack

This study evaluates an inactivated Salmonella Typhimurium vaccine in pigs, showing strong and long-lasting immune responses with improved safety and seroconversion compared to live vaccines.

bioRxiv · Mar 27, 2023Immunology

Microbiota colonization tunes the antigen threshold of microbiota-specific T cell activation in the gut

D. Hoces, B. Corak, A. Estrada Brull, S. Berent, E. Faccin, C. Moresi, T. Keys, N. Joller, E. Slack

This study shows that microbiota colonization affects T cell activation thresholds in the gut, with immune system status and TCR specificity influencing responses to colonizing bacteria.

bioRxiv · Jul 29, 2022 · PreprintImmunology

Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide is dependent on the resident microbiota

D. Hoces, G. Greter, M. Arnoldini, C. Moresi, S. Berent, I. Kolinko, F. Bansept, A. Woller, J. Häfliger, E. Martens, W.-D. Hardt, C. Loverdo, E. Slack

This study quantifies colonization bottlenecks and growth dynamics of Bacteroides thetaiotaomicron in the gut, showing that capsular polysaccharide provides a fitness advantage dependent on microbiota composition.

bioRxiv · Jun 19, 2022Microbiology

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria

M. Lucienne, R. Gerlini, B. Rathkolb, J. Calzada-Wack, P. Forny, S. Wüest, A. Kaech, F. Traversi, M. Forny, C. Bürer, J. A. Aguilar-Pimentel, M. Irmler, J. Beckers, S. Sauer, S. Kölker, , M. Hrabe de Angelis

This study examines a mouse model of methylmalonic aciduria, finding reduced energy expenditure, altered metabolism, and metabolic inflexibility.

bioRxiv · Nov 30, 2021Physiology

Metabolic reconstitution by a gnotobiotic microbiota varies over the circadian cycle

D. Hoces, J. Lan, W. Sun, T. Geiser, E. Cappio Barazzone, M. Arnoldini, S. Nowok, A. J. Macpherson, B. Stecher, R. Zenobi, W.-D. Hardt, C. Wolfrum, E. Slack

This study shows that a gnotobiotic microbiota affects metabolic processes differently depending on the circadian cycle, influencing energy balance and substrate utilization.

bioRxiv · Sep 8, 2021Microbiology

A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

M. Diard, E. Bakkeren, D. Hoces, V. Lentsch, M. Arnoldini, F. Boehi, K. Schumann-Moor, J. Adamcik, L. Piccoli, A. Lanzavecchia, B. Stadtmueller, N. Donohue, M. Vanderwoude, P. Viollier, L. Falquet, , E. Slack

This paper shows that an oral vaccine inducing IgA in mice can direct Salmonella to evolve into less virulent variants with shorter O-antigens.

bioRxiv · May 13, 2021Immunology