A. R. Hall

Antibiotic-degrading resistance changes bacterial community structure via species-specific responses

The paper investigates how antibiotic-degrading resistance in one species affects multispecies bacterial communities, finding that species benefiting most are those that grow best at degraded antibiotic concentrations.

Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans

This study shows type IV-A3 CRISPR-Cas systems use host adaptation machinery to update their CRISPR arrays and interfere with plasmid and phage transfer, supporting their role in plasmid competition.

Design principles of Cdr2 node patterns in fission yeast cells

The paper investigates how Cdr2 nodes form and position in fission yeast cells using experimental and modeling approaches, finding that tip inhibition and cortical anchoring are sufficient for node assembly without a nucleus.

Clinical Antibiotic-Resistance Plasmids Have Small Effects on Biofilm Formation and Population Growth in Escherichia coli in vitro

This study tests how clinical antibiotic-resistance plasmids affect biofilm formation and growth in Escherichia coli, finding small or no effects in most cases.

Anillin Related Mid1 as an Adaptive and Multimodal Contractile Ring Anchoring Protein: A Simulation Study

This study simulates Mid1's membrane binding mechanisms, showing multiple binding modes involving its PH and C2 domains, and how these contribute to its role in cytokinetic ring anchoring.

Injury and a program of fetal wound healing in the fetal and neonatal extrahepatic bile duct

This study investigates the fetal response to injury in extrahepatic bile ducts (EHBDs) and identifies a fetal wound healing program characterized by high molecular weight HA, which may lead to obstruction in biliary atresia.

Computational and in vitro evaluation of probiotic treatments for nasal Staphylococcus aureus decolonization

This paper evaluates probiotic and antibiotic treatments for nasal Staphylococcus aureus decolonization using computational modeling and in vitro experiments, finding probiotics outperform antibiotics in decolonization and recolonization robustness.

Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmids

The paper shows strain-specific evolution of plasmid-stability traits in bacteria influences long-term plasmid stability, overriding initial bacterium-plasmid combination differences.

Community Composition of Bacteria Isolated from Swiss Banknotes Varies Depending on Collection Environment

The paper shows that bacterial communities on Swiss banknotes vary by local shop type rather than geographic distance.

A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

The paper proposes a mechanism involving severing near barbed ends and annealing to explain the structure and dynamics of dendritic actin networks in lamellipodia.

Exposure to lysed bacteria can promote or inhibit growth of neighbouring live bacteria depending on local abiotic conditions

The paper shows that lysed bacteria can suppress growth of neighboring live bacteria in nutrient-rich conditions, suggesting a non-nutritional ecological role for dead cells.

In vitro gut modeling as a tool for adaptive evolutionary engineering of Lactiplantibacillus plantarum

This paper uses an in vitro gut model to evolve Lactiplantibacillus plantarum strains adapted to the human colonic environment, identifying beneficial mutations that enhance colonization.

Evolution of Honey Resistance in Experimental Populations of Bacteria Depends on the Type of Honey, and Has no Major Side Effects for Antibiotic Susceptibility

This study isolates honey-resistant E. coli mutants and finds limited resistance development with small effects on antibiotic susceptibility.

Human-associated microbiota suppress invadingbacteria even under disruption by antibiotics

The paper shows that human-associated microbiota suppress invading antibiotic-resistant bacteria, even after antibiotic exposure, with suppression strength linked to donor-specific community composition.

Microbial community composition interacts with local abiotic conditions to drive colonization resistance in human gut microbiome samples

Insights into actin polymerization and nucleation using a coarse grained model

This study uses a coarse-grained model to simulate actin polymerization and nucleation, revealing binding dynamics and structural configurations at barbed and pointed ends.

Antibiotics in microbial communities: an ecological frame of resistance

This paper uses ecological theory to explore how competitive ability and niche overlap influence antibiotic resistance and pathogen persistence in microbial communities.

Collateral sensitivity interactions between antibiotics depend on local abiotic conditions

The paper shows that collateral sensitivity between antibiotics varies with environmental conditions by affecting mutant selection and antibiotic expression.

FITNESS BENEFITS TO BACTERIA OF CARRYING PROPHAGES AND PROPHAGE-ENCODED ANTIBIOTIC-RESISTANCE GENES PEAK IN DIFFERENT ENVIRONMENTS

The paper examines how prophage-encoded antibiotic resistance genes (ARGs) and prophage carriage affect bacterial fitness in different environments, finding that their benefits peak under distinct conditions.

Estimating plasmid conjugation rates: a new computational tool and a critical comparison of methods

The paper introduces a new computational tool for estimating plasmid conjugation rates and compares existing methods, showing biases due to population dynamics and growth differences.

Clinical extended-spectrum beta-lactamase antibiotic resistance plasmids have diverse transfer rates and can spread in the absence of antibiotic selection

This study quantifies the conjugative transfer dynamics of ESBL plasmids in vitro and in vivo, showing variation in transfer efficiency and potential for predicting plasmid spread.

Resident microbial communities inhibit growth and antibiotic resistance evolution of Escherichia coli in human gut microbiome samples

This study shows that resident gut microbial communities suppress growth and prevent antibiotic resistance evolution in E. coli, even when resistance genes are present in the community.