M. Diard

Phenotypic heterogeneity drives phage-bacteria coevolution in the intestinal tract

This study shows that phenotypic heterogeneity in bacteria affects phage-bacteria coevolution, leading to phage extinction due to genetic resistance evolution in the intestinal tract.

Vaccine-enhanced competition permits rational bacterial strain replacement in the gut

The paper demonstrates that oral vaccination combined with engineered competitor strains can exclude pathogens and replace bacterial strains in the mouse gut.

The expression of virulence increases outer-membrane permeability and sensitivity to envelope stress in Salmonella Typhimurium

This study shows that upregulating virulence in Salmonella Typhimurium increases membrane permeability and stress sensitivity, revealing a trade-off between virulence and stress resistance.

A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

This paper shows that an oral vaccine inducing IgA in mice can direct Salmonella to evolve into less virulent variants with shorter O-antigens.

Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

This study shows that plasmid dissemination in the gut is enhanced by antibiotic degradation in the lumen and cycling between gut and tissue reservoirs in Salmonella Typhimurium.

Cooperative virulence can emerge via horizontal gene transfer but is stabilized by transmission

This study shows that horizontal gene transfer can enable virulence in Salmonella Typhimurium, but cooperative virulence is stabilized by transmission dynamics and population bottlenecks.

Clinical extended-spectrum beta-lactamase antibiotic resistance plasmids have diverse transfer rates and can spread in the absence of antibiotic selection

This study quantifies the conjugative transfer dynamics of ESBL plasmids in vitro and in vivo, showing variation in transfer efficiency and potential for predicting plasmid spread.

Enchained growth and cluster dislocation: a possible mechanism for microbiota homeostasis

The paper investigates how IgA antibodies affect bacterial growth and clustering in the gut, finding that faster replicating bacteria are more affected by IgA-mediated chain breaking.