Author

E. Barbosa da Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. J. O'Donoghue· 2 shared J. H. McKerrow· 2 shared J. L. Siqueira-Neto· 2 shared A. B. Chase· 1 shared A. Bogdanov· 1 shared A. L. Lourenco· 1 shared A. Poso· 1 shared B. Woodworth· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

A. J. O'Donoghue

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Author profile →

3 papers

Recent·Most cited

Small Molecule in situ Resin Capture - A Compound First Approach to Natural Product Discovery.

A. Bogdanov, M. N. Salib, A. B. Chase, H. Hammerlindl, M. N. Muskat, S. Luedtke, E. Barbosa Da Silva, A. J. O'Donoghue, L. F. Wu, S. J. Altschuler, T. F. Molinski, P. R. Jensen

This paper introduces a compound-first approach to natural product discovery called SMIRC, which captures structurally complex small molecules directly from environments, leading to the discovery of new compounds and classes.

bioRxiv · Mar 2, 2023 · PreprintBiochemistry

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

L. H. Santos, T. Kronenberger, R. G. Almeida, E. Barbosa da Silva, R. E. O. Rocha, J. C. Oliveira, L. V. Barreto, D. Skinner, P. Fajtova, M. A. Giardini, B. Woodworth, C. Bardine, A. L. Lourenco, C. S. Craik, A. Poso, , R. Ferreira

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

bioRxiv · Jan 5, 2022Biochemistry

Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents Against Trypanosoma cruzi

J. A. Bernatchez, Y.-S. Kil, E. Barbosa da Silva, D. Thomas, L.-I. McCall, K. L. Wendt, J. M. Souza, J. Ackermann, J. H. McKerrow, R. H. Cichewicz, J. L. Siqueira-Neto

This study identifies leucinostatins from fungi as potent antiparasitic agents against Trypanosoma cruzi, with one showing in vivo efficacy in a mouse model.

bioRxiv · May 30, 2021Microbiology