Author

J. L. Siqueira-Neto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 3 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. A. Bernatchez· 6 shared S. Beck· 6 shared J. H. McKerrow· 5 shared A. E. Clark· 4 shared Z. Zhu· 4 shared B. W. Purse· 2 shared D. Skinner· 2 shared E. Barbosa da Silva· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersMicrobiology

J. A. Bernatchez

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Author profile →

10 papers

Recent·Most cited

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

L. H. Santos, T. Kronenberger, R. G. Almeida, E. Barbosa da Silva, R. E. O. Rocha, J. C. Oliveira, L. V. Barreto, D. Skinner, P. Fajtova, M. A. Giardini, B. Woodworth, C. Bardine, A. L. Lourenco, C. S. Craik, A. Poso, , R. Ferreira

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

bioRxiv · Jan 5, 2022Biochemistry

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.

A. Sen, B. C. Prager, D. Park, Z. Zhu, R. C. Gimple, J. A. Bernatchez, S. Beck, A. E. Clark, J. L. Siqueira-Neto, J. N. Rich, G. P. McVicker

This study identifies genes with allele-specific expression in glioblastoma stem cells, finding SLFN11 loss linked to drug resistance and susceptibility to Zika virus.

bioRxiv · Jun 22, 2021Cancer Biology

Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents Against Trypanosoma cruzi

J. A. Bernatchez, Y.-S. Kil, E. Barbosa da Silva, D. Thomas, L.-I. McCall, K. L. Wendt, J. M. Souza, J. Ackermann, J. H. McKerrow, R. H. Cichewicz, J. L. Siqueira-Neto

This study identifies leucinostatins from fungi as potent antiparasitic agents against Trypanosoma cruzi, with one showing in vivo efficacy in a mouse model.

bioRxiv · May 30, 2021Microbiology

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

D. Mellott, C.-T. Tseng, A. Drelich, P. Fajtova, B. C. Chenna, D. Kostomiris, J. C. Hsu, J. Zhu, Z. Taylor, V. Tat, A. Katzfuss, L. Li, M. A. Giardini, D. Skinner, K. Hirata, , J. H. McKerrow

This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.

bioRxiv · Oct 23, 2020 · PreprintBiochemistry

Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas disease

D. A. Dean, Gautham, J. L. Siqueira-Neto, J. H. McKerrow, P. C. Dorrestein, L.-I. McCall

The paper uses spatial metabolomics to identify localized metabolic changes in heart tissue of mice chronically infected with Trypanosoma cruzi, revealing distinct metabolic perturbations from parasite burden sites.

bioRxiv · Jun 29, 2020Biochemistry

Machine Learning Models Identify Inhibitors of SARS-CoV-2

V. O. Gawriljuk, P. P. Kyaw Zin, D. H. Foil, J. Bernatchez, S. Beck, N. Beutler, J. Ricketts, L. Yang, T. Rogers, A. C. Puhl, K. M. Zorn, T. R. Lane, A. S. Godoy, G. Olivia, J. L. Siqueira-Neto, , S. Ekins

The paper uses machine learning to predict SARS-CoV-2 inhibitors from FDA-approved compounds, identifying CPI1062 and CPI1155 as potential antiviral drugs.

bioRxiv · Jun 16, 2020Pharmacology & Toxicology

High-throughput screening of the ReFRAME library identifies potential drug repurposing candidates for Trypanosoma cruzi

J. A. Bernatchez, E. Chen, M. V. Hull, C. W. McNamara, J. H. McKerrow, J. L. Siqueira-Neto

The paper screens 12,000 compounds from the ReFRAME library against Trypanosoma cruzi, identifying 7 with potent in vitro activity and therapeutic index ≥10.

bioRxiv · Dec 11, 2019Microbiology

Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells

J. A. Bernatchez, M. Coste, S. Beck, G. A. Wells, L. A. Luna, A. E. Clark, Z. Zhu, C. D. Sohl, B. W. Purse, J. L. Siqueira-Neto

This study evaluates the antiviral activity of nucleoside ProTides against Zika virus in human neural stem cells, identifying effective compounds and elucidating their mechanism of action.

bioRxiv · Jan 29, 2019Microbiology

Mechanism of action of methotrexate against Zika virus

S. Beck, J. A. Bernatchez, Z. Zhu, M. F. Oliveira, D. M. Smith, J. L. Siqueira-Neto

This study investigates how methotrexate inhibits Zika virus replication by targeting the dihydrofolate reductase pathway and shows that adenosine depletion also contributes to its antiviral effect.

bioRxiv · Nov 29, 2018Microbiology

Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus

J. A. Bernatchez, Z. Yang, M. Coste, J. Li, S. Beck, Y. Liu, A. E. Clark, Z. Zhu, L. A. Luna, C. Sohl, B. W. Purse, R. Li, J. L. Siqueira-Neto

The paper develops and validates a high-content imaging assay to assess antiviral activity of small-molecule inhibitors against Zika virus by detecting cytopathic effects.

bioRxiv · Apr 17, 2018Microbiology