Author

T. Malinauskas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:human· 3 Organism:virus· 3 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

D. I. Stuart· 3 shared H. M. E. Duyvesteyn· 3 shared J. Huo· 3 shared P. Rijal· 3 shared T. K. Tan· 3 shared A. Townsend· 2 shared D. Zhou· 2 shared E. E. Fry· 2 shared

Activity by Year

2020-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

D. I. Stuart

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

M. Emmenegger, S. S. Kumar, V. Emmenegger, T. Malinauskas, T. Buettner, L. Rose, P. Schierack, M. F. Sprinzl, C. J. Sommer, K. J. Lackner, A. Aguzzi, D. Roggenbuck, K. B. M. Frauenknecht

This study finds that anti-prothrombin autoantibodies are enriched after SARS-CoV-2 infection and linked to antibody response strength and disease severity.

bioRxiv · Jun 21, 2021Immunology

Site-specific steric control of SARS-CoV-2 spike glycosylation

J. D. Allen, H. Chawla, F. Samsudin, L. Zuzic, A. T. Shivgan, Y. Watanabe, W.-T. He, S. Callaghan, G. Song, P. Yong, P. J. M. Brouwer, Y. Song, Y. Cai, H. M. E. Duyvesteyn, T. Malinauskas, , M. Crispin

The paper compares glycosylation patterns of recombinant SARS-CoV-2 spike proteins across labs with infectious virus S protein, finding conserved site-specific glycan maturation stalling linked to protein structure.

bioRxiv · Mar 8, 2021 · PreprintBiochemistry

Single-particle cryo-EM at atomic resolution

T. Nakane, A. Kotecha, A. Sente, G. McMullan, S. Masiulis, P. M. G. E. Brown, I. T. Grigoras, L. Malinauskaite, T. Malinauskas, J. Miehling, L. Yu, D. Karia, E. V. Pechnikova, E. de Jong, J. Keizer, , S. Scheres

This paper demonstrates achieving atomic resolution cryo-EM structures for membrane proteins and apo-ferritin using advanced hardware, enabling detailed structural analysis and hydrogen bonding visualization.

Nature · Oct 21, 2020Peer-reviewedBiophysics

Neutralization of SARS-CoV-2 by destruction of the prefusion Spike

J. Huo, Y. Zhao, J. Ren, D. Zhou, H. M. E. Duyvesteyn, H. M. Ginn, L. Carrique, T. Malinauskas, R. R. Ruza, P. N. Shah, T. K. Tan, P. Rijal, N. Coombes, K. Bewley, J. Radecke, , D. I. Stuart

This paper identifies CR3022 as a monoclonal antibody that neutralizes SARS-CoV-2 by destroying its prefusion Spike conformation, suggesting therapeutic potential.

Cell Host & Microbe · Sep 1, 2020Peer-reviewedMicrobiology

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

T. K. Tan, P. Rijal, R. Rahikainen, A. Keeble, L. Schimanski, S. Hussain, R. Harvey, J. Hayes, J. Edwards, R. McLean, V. Martini, M. Pedrera, N. Thakur, C. Conceicao, I. Dietrich, , R. Owens

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

bioRxiv · Aug 31, 2020Immunology

Structure and Dynamics of HIV-1 Env Trimers on Native Virions Engaged in Living T Cells

I. Carlon Andres, T. Malinauskas, S. Padilla-Parra

This study investigates the conformational dynamics of HIV-1 Env trimers on virions interacting with live T cells, revealing how Env clustering and intramolecular dynamics influence immune evasion.

bioRxiv · Aug 16, 2020Immunology

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

D. Zhou, H. M. E. Duyvesteyn, C.-P. Chen, C.-G. Huang, T.-H. Chen, S.-R. Shih, Y.-C. Lin, C.-Y. Cheng, S.-H. Cheng, Y.-C. Huang, T.-Y. Lin, C. Ma, J. Huo, L. Carrique, T. Malinauskas, , K.-Y. A. Huang

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

bioRxiv · Jun 12, 2020Microbiology