E. Fischer-Friedrich

Epithelial folding through local degradation of an elastic basement membrane plate

The paper develops a model showing local basement membrane degradation drives epithelial folding without epithelial growth.

EMT induces cell-cycle-dependent changes of Rho GTPases and downstream effectors

The paper shows EMT in breast cancer cells causes cell-cycle-dependent changes in Rho GTPases and downstream effectors, proposing two new signalling pathways.

Hydrostatic pressure and lateral actomyosin tension control stretch and tension of the basement membrane in epithelia

The paper measures basal tension in Drosophila wing disc epithelium and finds it depends on actomyosin and basement membrane, proportional to hydrostatic pressure and lateral tension.

Skin epithelial cells change their mechanics and proliferation upon Snail-mediated EMT signalling

This study shows that Snail-mediated EMT in skin epithelial cells alters cellular mechanics, mitotic rounding, and proliferation, with implications for skin tumor progression.

EMT changes actin cortex rheology in a cell-cycle dependent manner

This study examines how EMT affects actin cortex rheology in human epithelial cells, finding cell-cycle dependent softening in interphase and stiffening in mitosis.

Binding dynamics of α-actinin-4 in dependence of actin cortex tension

The paper quantifies how -actinin-4 binding dynamics depend on actin cortex tension in live cells, showing it acts as a catch bond under physiological tension.

EMT-induced cell mechanical changes enhance mitotic rounding strength

This study shows that EMT in breast epithelial cells enhances mitotic rounding strength through changes in Rho GTPase activity, aiding cancer cells in mitosis under mechanical stress.

3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK

This study shows that 3D microenvironment stiffness affects tumor spheroid growth and mechanics through p21 and ROCK pathways.