I. Poser

Chemical inhibition of the integrated stress response impairs the ubiquitin-proteasome system

The paper shows that ISRIB impairs UPS degradation in the cytosol during proteotoxic stress, particularly affecting RQC and leading to UPS dysfunction.

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

Molecular mechanisms of stress-induced reactivation in mumps virus condensates

The paper investigates how cellular stress triggers reactivation of persistent mumps virus infection through molecular and structural changes in viral condensates.

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain

This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.

Binding dynamics of α-actinin-4 in dependence of actin cortex tension

The paper quantifies how -actinin-4 binding dynamics depend on actin cortex tension in live cells, showing it acts as a catch bond under physiological tension.

A localization screen reveals translation factories and widespread co-translational RNA targeting

The paper identifies translation factories and co-translational RNA targeting through a dual protein/mRNA localization screen in human cells.