CUX1 and IκBζ mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts
K. Slowikowski, H. N. Nguyen, E. H. Noss, D. P. Simmons, F. Mizoguchi, G. F. Watts, M. F. Gurish, M. B. Brenner, S. Raychaudhuri
The paper identifies CUX1 and IκBζ as key mediators of the synergistic inflammatory response to TNF and IL-17A in human synovial fibroblasts, leading to IL-6 production and neutrophil recruitment.
bioRxiv · Mar 11, 2019Immunology