Author

L. T. Donlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Research Focus:cell type annotation· 7 Organism:human· 7 Assay:scRNA-seq· 6 Approach:experimental assay· 5 Research Focus:cell-cell communication· 4 Research Focus:differential expression· 4 Assay:flow cytometry· 4 Approach:statistical model· 4

Frequent Co-Authors

D. A. Rao· 6 shared K. Wei· 6 shared M. B. Brenner· 6 shared S. M. Goodman· 6 shared S. Raychaudhuri· 6 shared V. P. Bykerk· 5 shared A. Filer· 4 shared F. Zhang· 4 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

D. A. Rao

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis

K. Weinand, S. Sakaue, A. Nathan, A. H. Jonsson, F. Zhang, G. F. M. Watts, Z. Zhu, Accelerating Medicines Partnership Program: RA and SLE Network, D. A. Rao, J. H. Anolik, M. B. Brenner, L. T. Donlin, K. Wei, S. Raychaudhuri

The paper identifies chromatin classes in RA synovial tissue and links them to transcriptional cell states and genetic variants.

bioRxiv · Apr 7, 2023 · PreprintImmunology

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium

G. S. Dunlap, A. Wagner, N. Meednu, F. Zhang, A. H. Jonsson, K. Wei, S. Sakaue, A. Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (A, V. P. Bykerk, L. T. Donlin, S. M. Goodman, G. S. Firestein, D. L. Boyle, V. M. Holers, , J. Anolik

This study uses single-cell antigen receptor profiling to identify clonal relationships and functional states of T and B cells in RA synovium.

bioRxiv · Mar 18, 2023 · PreprintImmunology

Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis

R. Wang, A. Singaraju, K. E. Marks, L. Shakib, G. S. Dunlap, A. Cunningham-Bussel, L. Chen, A. Tirpack, M. R. Fein, D. J. Todd, L. MacFarlane, S. M. Goodman, E. F. DiCarlo, E. M. Massarotti, J. A. Sparks, , D. A. Rao

This study identifies a distinct CD38hi cytotoxic CD8 T cell subset in ICI-induced arthritis, showing clonal expansion and IFN-driven activation.

bioRxiv · Oct 19, 2021 · PreprintImmunology

HBEGF+ macrophages identified in rheumatoid arthritis promote joint tissue invasiveness and are reshaped differentially by medications

D. Kuo, J. Ding, I. Cohn, F. Zhang, K. Wei, D. Rao, C. Rozo, U. K. Sokhi, Accelerating Medicines Partnership RA/SLE Network, E. F. DiCarlo, M. B. Brenner, V. P. Bykerk, S. M. Goodman, S. Raychaudhuri, G. Rätsch, , L. T. Donlin

A newly identified human macrophage phenotype in RA promotes joint tissue invasiveness and shows variable responses to anti-inflammatory medications.

bioRxiv · Jan 31, 2019 · PreprintImmunology

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

F. Zhang, K. Wei, K. Slowikowski, C. Y. Fonseka, D. A. Rao, S. Kelly, S. M. Goodman, D. Tabechian, L. B. Hughes, K. Salomon-Escoto, G. F. M. Watts, W. Apruzzese, D. J. Lieb, D. L. Boyle, A. M. Mandelin, , S. Raychaudhuri

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

bioRxiv · Jun 20, 2018Immunology

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

L. T. Donlin, D. A. Rao, K. Wei, K. Slowikowski, M. J. McGeachy, J. D. Turner, N. Meednu, F. Mizoguchi, M. Gutierrez-Arcelus, D. J. Lieb, J. Keegan, K. Muskat, J. Hillman, C. Rozo, E. Ricker, , M. B Brenner

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

bioRxiv · Mar 19, 2018Immunology

Single Cell Transcriptomics And Flow Cytometry Reveal Disease-Associated Fibroblast Subsets In Rheumatoid Arthritis

F. Mizoguchi, K. Slowikowski, J. L. Marshall, K. Wei, D. A. Rao, S. K. Chang, H. N. Nguyen, E. H. Noss, J. D. Turner, B. E. Earp, P. E. Blazar, J. Wright, B. P. Simmons, L. T. Donlin, G. D. Kalliolias, , M. B. Brenner

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.

bioRxiv · May 26, 2017Immunology