Author

K. Slowikowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Organism:human· 8 Research Focus:cell type annotation· 7 Research Focus:differential expression· 7 Assay:scRNA-seq· 6 Approach:statistical model· 6 Research Focus:cell-cell communication· 5 Assay:bulk RNA-seq· 4 Approach:deep learning· 4

Frequent Co-Authors

S. Raychaudhuri· 6 shared N. Hacohen· 4 shared A. Filer· 3 shared D. A. Rao· 3 shared F. Mizoguchi· 3 shared J. A. Lederer· 3 shared K. Wei· 3 shared L. T. Donlin· 3 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

S. Raychaudhuri

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Author profile →

8 papers

Recent·Most cited

Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor

S. M. Blum, D. A. Zlotoff, N. P. Smith, I. J. Kernin, S. Ramesh, L. Zubiri, J. Caplin, N. Samanta, S. C. Martin, A. Tirard, P. Sen, Y. Song, J. L. Barth, K. Slowikowski, M. Nasrallah, , A.-C. Villani

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

bioRxiv · Sep 15, 2023 · PreprintImmunology

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

M. Thomas, K. Slowikowski, K. Manakongtreecheep, P. Sen, J. Tantivit, M. Nasrallah, N. Smith, S. Ramesh, L. Zubiri, A. Tirard, B. Arnold, L. Nieman, J. Chen, T. Eisenhaure, K. Pelka, , A.-C. Villani

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

bioRxiv · Sep 17, 2021Immunology

Insights from Comparison of the Renal and Skin Single Cell Transcriptomes in Lupus Nephritis

E. Der, H. Suryawanshi, P. Morozov, M. Kustagi, B. Goilav, S. Ranabathou, P. Izmirly, R. Clancy, H. M. Belmont, M. Koenigsberg, M. Mokrzycki, H. Rominieki, J. Graham, J. Rocca, N. Bornkamp, , C. Putterman

This study uses scRNA-seq to analyze renal and skin biopsies from lupus nephritis patients, identifying IFN signatures and fibrotic pathways associated with disease heterogeneity and non-response.

bioRxiv · Dec 31, 2019 · PreprintImmunology

CUX1 and IκBζ mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts

K. Slowikowski, H. N. Nguyen, E. H. Noss, D. P. Simmons, F. Mizoguchi, G. F. Watts, M. F. Gurish, M. B. Brenner, S. Raychaudhuri

The paper identifies CUX1 and IκBζ as key mediators of the synergistic inflammatory response to TNF and IL-17A in human synovial fibroblasts, leading to IL-6 production and neutrophil recruitment.

bioRxiv · Mar 11, 2019Immunology

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

F. Zhang, K. Wei, K. Slowikowski, C. Y. Fonseka, D. A. Rao, S. Kelly, S. M. Goodman, D. Tabechian, L. B. Hughes, K. Salomon-Escoto, G. F. M. Watts, W. Apruzzese, D. J. Lieb, D. L. Boyle, A. M. Mandelin, , S. Raychaudhuri

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

bioRxiv · Jun 20, 2018Immunology

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

L. T. Donlin, D. A. Rao, K. Wei, K. Slowikowski, M. J. McGeachy, J. D. Turner, N. Meednu, F. Mizoguchi, M. Gutierrez-Arcelus, D. J. Lieb, J. Keegan, K. Muskat, J. Hillman, C. Rozo, E. Ricker, , M. B Brenner

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

bioRxiv · Mar 19, 2018Immunology

A genome-wide innateness gradient defines the functional state of human innate T cells

M. Gutierrez-Arcelus, N. Teslovich, A. R. Mola, H. Kim, S. Hannes, K. Slowikowski, G. F. M. Watts, M. Brenner, S. Raychaudhuri, P. J. Brennan

The paper identifies an innateness gradient in human T cells, showing a trade-off between effector function and proliferative capacity.

bioRxiv · Mar 13, 2018Immunology

Single Cell Transcriptomics And Flow Cytometry Reveal Disease-Associated Fibroblast Subsets In Rheumatoid Arthritis

F. Mizoguchi, K. Slowikowski, J. L. Marshall, K. Wei, D. A. Rao, S. K. Chang, H. N. Nguyen, E. H. Noss, J. D. Turner, B. E. Earp, P. E. Blazar, J. Wright, B. P. Simmons, L. T. Donlin, G. D. Kalliolias, , M. B. Brenner

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.

bioRxiv · May 26, 2017Immunology