Author

E. Haythorne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Georgiadou· 2 shared G. A. Rutter· 2 shared I. Leclerc· 2 shared A. C. H. Fung· 1 shared A. Cakebread· 1 shared A. K. K. Teo· 1 shared A. Martinez-Sanchez· 1 shared A. Mueller· 1 shared

Activity by Year

2019-2020 · peak 1/yr

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10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

E. Georgiadou

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2 papers

Recent·Most cited

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

G. R. Carrat, E. Haythorne, A. Tomas, L. Haataja, A. Mueller, P. Arvan, A. Piunti, K. Cheng, M. Huang, T. Pullen, E. Georgiadou, T. Stylianides, N. S. Amirruddin, V. Salem, W. Distaso, , G. A. Rutter

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

Molecular Metabolism · Oct 1, 2020Peer-reviewedCell Biology

The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

E. Haythorne, E. Georgiadou, M. Dickerson, L. Lopez Noriega, T. J. Pullen, G. da Silva Xavier, S. Davis, A. Martinez-Sanchez, F. Semplici, R. Rizzuto, J. A. McGinty, P. M. French, M. C. Cane, D. A. Jacobson, I. Leclerc, G. A. Rutter

This study shows that the mitochondrial Ca2+ uniporter MCU is essential for normal glucose-stimulated insulin secretion in pancreatic beta-cells, both in vitro and in vivo.

bioRxiv · Sep 25, 2019Physiology