Author

G. da Silva Xavier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Martinez-sanchez· 2 shared G. A. Rutter· 2 shared I. Leclerc· 2 shared C. Flaxman· 1 shared D. A. Jacobson· 1 shared D. J. Hodson· 1 shared D. Larner· 1 shared D. Nasteska· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

A. Martinez-sanchez

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Author profile →

3 papers

Recent·Most cited

Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice

M.-S. Nguyen-Tu, A. Martinez-sanchez, I. Leclerc, G. A. Rutter, G. Da Silva Xavier

This study shows that reducing TCF7L2 in adipocytes impairs glucose tolerance in male mice through decreased insulin secretion, incretins, and lipid metabolism dysregulation, with effects dependent on gender, age, and diet.

bioRxiv · May 18, 2020 · PreprintPhysiology

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

K. Viloria, D. Nasteska, L. J. B. Briant, S. Helsing, D. Larner, N. H. F. Fine, F. B. Ashford, G. da Silva Xavier, M. Jimenez Ramos, J. E. Manning Fox, P. E. MacDonald, I. Akerman, G. G. Lavery, C. Flaxman, N. G. Morgan, , D. J. Hodson

This study shows that vitamin D-binding protein (DBP) is essential for maintaining β-cell function and glucagon secretion, with reduced DBP expression observed in late-onset type 1 diabetes.

bioRxiv · Dec 19, 2019 · PreprintPhysiology

The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

E. Haythorne, E. Georgiadou, M. Dickerson, L. Lopez Noriega, T. J. Pullen, G. da Silva Xavier, S. Davis, A. Martinez-Sanchez, F. Semplici, R. Rizzuto, J. A. McGinty, P. M. French, M. C. Cane, D. A. Jacobson, I. Leclerc, G. A. Rutter

This study shows that the mitochondrial Ca2+ uniporter MCU is essential for normal glucose-stimulated insulin secretion in pancreatic beta-cells, both in vitro and in vivo.

bioRxiv · Sep 25, 2019Physiology