Author

E. J. Tyler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

O. M. T. Pearce· 2 shared V. Gauthier· 2 shared A. Cameron· 1 shared A. Gutierrez Del Arroyo· 1 shared A. White· 1 shared B. K. Hughes· 1 shared C. Butterworth· 1 shared C. L. Bishop· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

O. M. T. Pearce

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function

E. P. Carter, K. K. Yoneten, N. Gavara, E. J. Tyler, V. Gauthier, E. Murray, A. Cameron, O. M. T. Pearce, R. P. Grose

The paper investigates the opposing roles of ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function in pancreatic cancer stellate cells using 3D chimeric spheroids and bulk-RNA sequencing.

bioRxiv · Sep 20, 2022Cancer Biology

Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis

E. H. Puttock, E. J. Tyler, M. Manni, E. Maniati, C. Butterworth, E. Peerani, P. Hirani, V. Gauthier, Y. Liu, G. Maniscalco, V. Rajeeve, P. Cutillas, C. Trevisan, M. Pozzobon, M. Lockley, , O. M. T. Pearce

The paper shows that the tumor extracellular matrix educates macrophages to adopt a phenotype seen in ovarian cancer metastasis, affecting T cell function and immune regulation.

bioRxiv · Aug 11, 2022 · PreprintCancer Biology

Early growth response 2 (EGR2) is a novel regulator of the senescence program

E. J. Tyler, A. Gutierrez Del Arroyo, R. Wallis, B. K. Hughes, J. C. Garbe, M. R. Stampfer, J. Koh, R. Lowe, M. P. Philpott, C. L. Bishop

This study identifies EGR2 as a novel regulator of senescence by activating the ARF and p16 promoters and reversing the senescent phenotype upon its ablation.

bioRxiv · Sep 30, 2020Cell Biology