Author

J. M. Beekman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Assay:organoid / primary culture· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

G. D. Amatngalim· 4 shared C. K. van der Ent· 3 shared L. W. Rodenburg· 3 shared W. Nijenhuis· 3 shared H. Clevers· 2 shared L. C. Kapitein· 2 shared M. D. Amaral· 2 shared M. Nijhuis· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCell Biology

G. D. Amatngalim

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Author profile →

6 papers

Recent·Most cited

Establishment and characterization of a new Pseudomonas aeruginosa infection model using 2D airway organoids and dual RNA sequencing

C. Pleguezuelos-Manzano, W. A. Beenker, G. J. F. van Son, H. Beghtel, G. D. Amatngalim, J. M. Beekman, H. Clevers, J. den Hertog

This study establishes a Pseudomonas aeruginosa infection model using 2D airway organoids and dual RNA sequencing to investigate host-bacterial interactions and quorum sensing effects.

bioRxiv · Mar 11, 2023 · PreprintMicrobiology

Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids

L. W. Rodenburg, L. Delpiano, V. Railean, R. Centeio, M. C. Pinto, S. M. A. Smits, I. S. van der Windt, C. F. J. van Hugten, S. F. B. van Beuningen, R. N. P. Rodenburg, C. K. van der Ent, M. D. Amaral, K. Kunzelmann, M. A. Gray, J. M. Beekman, G. D. Amatngalim

This study identifies 12 FDA-approved drugs that induce CFTR-independent fluid secretion in nasal organoids, offering potential treatment for CF patients unresponsive to CFTR modulators.

bioRxiv · Sep 23, 2022Cell Biology

The SARS-CoV-2 accessory factor ORF7a downregulates MHC class I surface expression

S. Zheng, H. de Buhr, P. Praest, A. Evers, I. Brak Boer, M. van Grinsven, Y. Longo, L. de Vries, W. Nijenhuis, L. C. Kapitein, J. M. Beekman, M. Nijhuis, I. Drexler, E. J. Wiertz, R. J. Lebbink

This study identifies SARS-CoV-2 ORF7a as a viral factor that downregulates MHC class I surface expression, impairing antigen presentation and immune surveillance.

bioRxiv · May 29, 2022 · PreprintMicrobiology

Optical nanoscopy reveals SARS-CoV-2-induced remodeling of human airway cells

W. Nijenhuis, H. G. J. Damstra, E. J. van Grinsven, M. K. Iwanski, P. Praest, Z. E. Soltani, M. M. P. van Grinsven, J. E. Brunsveld, T. M. De Kort, L. W. Rodenburg, D. C. M. de Jong, H. M. Raeven, S. Spelier, G. D. Amatngalim, A. Akhmanova, , L. C. M. Kapitein

This study uses advanced microscopy to show how SARS-CoV-2 changes the structure of human airway cells at the subcellular level.

bioRxiv · Aug 5, 2021 · PreprintCell Biology

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

G. D. Amatngalim, L. W. Rodenburg, B. L. Aalbers, H. H. M. Raeven, E. M. Aarts, I. A. L. Silva, W. Nijenhuis, S. Vrendenbarg, E. Kruisselbrink, J. Brunsveld, C. M. van Drunen, S. Michel, K. M. de Winter-de Groot, H. G. Heijerman, L. C. Kapitein, , J. M. Beekman

This study develops an improved method to measure CFTR drug responses in nasal airway organoids derived from 2D differentiated epithelial cells.

bioRxiv · Jul 20, 2021Cell Biology

Long-term expanding human airway organoids for disease modelling.

N. Sachs, D. D. Zomer-van Ommen, A. Papaspyropoulos, I. Heo, L. Bottinger, D. Klay, F. Weeber, G. Huelsz-Prince, N. Iakobachvili, M. C. Viveen, A. Lyubimova, L. Teeven, S. Derakhshan, J. Korving, H. Begthel, , H. Clevers

This study establishes long-term-expanding human airway organoids from broncho-alveolar biopsies or lavage material, enabling disease modeling of cystic fibrosis, lung cancer, and RSV infection.

bioRxiv · May 9, 2018Cell Biology