Author

E. L. Hesketh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Prodromou· 1 shared D. Bjorklund· 1 shared D. J. Filman· 1 shared E. Groppelli· 1 shared G. Degliesposti· 1 shared H. Munoz-Hernandez· 1 shared J. M. Hogle· 1 shared J. M. Skehel· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

C. Prodromou

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Author profile →

2 papers

Recent·Most cited

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

M. Pal, H. Munoz-Hernandez, D. Bjorklund, L. Zhou, G. Degliesposti, J. M. Skehel, E. L. Hesketh, R. F. Thompson, L. H. Pearl, O. Llorca, C. Prodromou

The paper determines the cryo-EM structure of the human R2TP-TTT complex and shows how TTT recruits TOR to R2TP while regulating its chaperone activity.

bioRxiv · Nov 9, 2020Biochemistry

Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate.

P. N. M. Shah, D. J. Filman, K. S. Karunatilaka, E. L. Hesketh, E. Groppelli, M. Strauss, J. M. Hogle

The paper identifies two distinct conformational states of the 135S poliovirus particle using cryo-EM, showing that VP1 N-terminus externalization and VP4 retention vary between states.

PLOS Pathogens · Sep 30, 2020Peer-reviewedBiophysics