Author

R. F. Thompson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:cryo-EM· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Nellore· 3 shared B. R. Weeder· 2 shared J. K. David· 2 shared M. A. Wood· 2 shared A. J. Struck· 1 shared A. Margolin· 1 shared A. Nguyen· 1 shared C. Prodromou· 1 shared

Activity by Year

2018-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. Nellore

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for dynamic inter-molecular interactions involved in viral genome replication

E. A. Loundras, J. Streetley, M. R. Herod, R. F. Thompson, M. Harris, D. Bhella, N. J. Stonehouse

This study identifies higher-order structures of the foot-and-mouth disease virus RdRp and their role in RNA replication through cryo-EM and mutagenesis.

bioRxiv · Dec 17, 2020 · PreprintMicrobiology

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

M. Pal, H. Munoz-Hernandez, D. Bjorklund, L. Zhou, G. Degliesposti, J. M. Skehel, E. L. Hesketh, R. F. Thompson, L. H. Pearl, O. Llorca, C. Prodromou

The paper determines the cryo-EM structure of the human R2TP-TTT complex and shows how TTT recruits TOR to R2TP while regulating its chaperone activity.

bioRxiv · Nov 9, 2020Biochemistry

Need for speed: Examining protein behaviour during cryoEM grid preparation at different timescales

D. P. Klebl, M. S. C. Gravett, D. Kontziampasis, D. J. Wright, R. S. Bon, D. Monteiro, M. Trebbin, F. Sobott, H. D. White, M. Darrow, R. F. Thompson, s. P. muench

This study examines how different macromolecular complexes behave during cryoEM grid preparation at various timescales using three vitrification devices.

bioRxiv · May 14, 2020Biochemistry

Burden of tumor mutations, neoepitopes, and other variants are dubious predictors of cancer immunotherapy response and overall survival

M. A. Wood, B. R. Weeder, J. K. David, A. Nellore, R. F. Thompson

This study evaluates tumor mutational burden (TMB) and related metrics as predictors of immunotherapy response and survival, finding limited predictive value in some cancers and instability in its use.

bioRxiv · Jan 28, 2020Cancer Biology

Putatively cancer-specific alternative splicing is shared across patients and present in developmental and other non-cancer cells

J. K. David, S. K. Maden, B. R. Weeder, R. F. Thompson, A. Nellore

The paper analyzes RNA-seq data to show that many cancer-specific splicing events are also present in non-cancer tissues and developmental cells, suggesting they may not be unique to cancer.

bioRxiv · Sep 5, 2019Cancer Biology

Population-level distribution and putative immunogenicity of cancer neoepitopes

M. A. Wood, M. Paralkar, M. P. Paralkar, A. Nguyen, A. J. Struck, K. Ellrott, A. Margolin, A. Nellore, R. F. Thompson

The paper introduces four metrics to prioritize neoepitopes based on peptide novelty and evaluates their immunogenicity using TCGA and melanoma patient data.

BMC Cancer · Apr 13, 2018Peer-reviewedCancer Biology