Author

I. B. Kotliar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Ceraudo· 3 shared E. Lorenzen· 2 shared J. M. Schwenk· 2 shared M. Uhlen· 2 shared T. Dodig-Crnkovic· 2 shared T. Huber· 2 shared T. P. Sakmar· 2 shared A. Bendes· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

E. Ceraudo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Expanding the GPCR-RAMP interactome

I. B. Kotliar, A. Bendes, L. Dahl, Y. Chen, M. Saarinen, E. Ceraudo, T. Dodig, M. Uhlen, P. Svenningsson, J. Schwenk, T. Sakmar

The paper identifies 122 GPCRs interacting with RAMPs using a DuET library and SBA assay, expanding the GPCR-RAMP interactome to inform therapeutic design.

bioRxiv · Nov 22, 2023Biochemistry

Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)

I. B. Kotliar, E. Ceraudo, K. Kemelmakher-Liben, D. A. Oren, E. Lorenzen, T. Dodig-Crnkovic, M. Horioka-Duplix, T. Huber, J. M. Schwenk, T. P. Sakmar

This study identifies that MRGPRX4 interacts with RAMP2, reducing its signaling and surface expression, and predicts the structure of the MRGPRX4-RAMP2 complex.

bioRxiv · Dec 6, 2022Biochemistry

Human caspase-1 autoproteolysis is required for ASC-dependent and -independent inflammasome activation

D. P. Ball, C. Y. Taabazuing, A. R. Griswold, E. L. Orth, S. D. Rao, I. B. Kotliar, D. C. Johnson, D. A. Bachovchin

This study shows that pro-caspase-1 autoproteolysis is required for both ASC-dependent and -independent inflammasome activation in human cells.

bioRxiv · Jun 24, 2019 · PreprintImmunology

Multiplexed Analysis of the Secretin-like GPCR-RAMP Interactome

E. Lorenzen, T. Dodig-Crnkovic, I. B. Kotliar, E. Pin, E. Ceraudo, R. D. Vaughan, M. Uhlen, T. Huber, J. M. Schwenk, T. P. Sakmar

This study identifies GPCR-RAMP interactions using a suspension bead array assay, revealing widespread interactions among secretin-like GPCRs and RAMPs.

bioRxiv · Apr 6, 2019Biochemistry