BCN057, a Modulator of GSK3β Induces KRAS G12D Mutant Pancreatic Cancer Cell Death
E. M. Singer, R. M. Chugh, P. Bhanja, A. Gomez, L. Gao, J. P. Whitelegge, W. H. McBride, S. Saha, A. J. Norris
This paper shows that BCN057, a GSK3β modulator, selectively induces apoptosis in KRAS G12D mutant pancreatic cancer cells while protecting normal intestinal epithelium.
bioRxiv · Sep 3, 2021 · PreprintCancer Biology