N. S. Chandel

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

Lymphocyte activation gene 3 (Lag3) supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis

This study shows Lag3 supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis, which is critical for suppressing autoimmune inflammation.

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming

This study identifies HOXB13's AR-independent role in suppressing lipogenesis via HDAC3-mediated epigenetic repression, linking its loss to metastatic prostate cancer progression.

SGK1 Signaling Promotes Glucose Metabolism and Survival in Extracellular Matrix Detached Cells

This study shows SGK1 promotes glucose metabolism and cell survival in ECM-detached cells by enhancing glucose uptake and PPP flux for ATP production.

Human iPSC-derived cerebral organoids model features of Leigh Syndrome and reveal abnormal corticogenesis

This study uses iPSC-derived cerebral organoids to model Leigh Syndrome, identifying defects in brain development and mitochondrial morphology.

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

This study examines proteome changes in alveolar macrophages and type 2 cells from young and old mice before and after influenza infection, revealing age-related proteostasis and mitochondrial dysfunction that worsen with infection.

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.