Conversion of cancer-associated fibroblasts from pro- to antitumor improves the sensitivity of pancreatic cancer to chemotherapeutics
T. Iida, Y. Mizutani, N. Esaki, S. M. Ponik, B. M. Burkel, L. Weng, K. Kuwata, A. Masamune, S. Ishihara, H. Haga, K. Kataoka, S. Mii, Y. Shiraki, T. Ishikawa, E. Ohno, , A. Enomoto
This study converts pro-tumor CAFs to anti-tumor CAFs using Meflin induction, enhancing PDAC chemosensitivity through improved drug delivery and reduced tissue stiffness.
bioRxiv · Jun 29, 2021 · PreprintCancer Biology