S. M. Ponik

Tumor Stroma Content Regulates Penetration and Efficacy of Tumor-targeting Bacteria

This study shows that high collagen content in tumors limits bacterial penetration and reduces the efficacy of Salmonella-based cancer therapy.

One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant

This paper introduces a one-pot exosome proteomics method using a photocleavable surfactant, enabling rapid and effective exosomal lysis, protein extraction, and digestion, with high reproducibility and coverage.

Conversion of cancer-associated fibroblasts from pro- to antitumor improves the sensitivity of pancreatic cancer to chemotherapeutics

This study converts pro-tumor CAFs to anti-tumor CAFs using Meflin induction, enhancing PDAC chemosensitivity through improved drug delivery and reduced tissue stiffness.

Cell-Scale Biophysical Cues from Collagen Fiber Architecture Instruct Cell Behavior and the Propagation of Mechanosensory Signals

This study shows that collagen fiber alignment affects cell-scale stiffness and mechanosensory signal propagation, influencing cell behavior and communication in the tumor microenvironment.

pHluo_M153R-CD63, a bright, versatile live cell reporter of exosome secretion and uptake, reveals pathfinding behavior of migrating cells

The paper introduces an improved exosome reporter, pHluorin-CD63 with M153R mutation, enabling stable visualization of exosome secretion and uptake in live cells and reveals their role in cell migration.