Author

E. P. Kusnadi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. S. Trigos· 2 shared C. Cullinane· 2 shared G. A. McArthur· 2 shared J. Kang· 2 shared R. B. Pearson· 2 shared A. D. Rao· 1 shared C. A. Martin· 1 shared D. Goode· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

A. S. Trigos

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2 papers

Recent·Most cited

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

E. P. Kusnadi, A. S. Trigos, C. Cullinane, D. L. Goode, O. S. Larsson, J. R. Devlin, K. T. Chan, D. P. DeSouza, M. J. McConville, G. A. McArthur, G. Thomas, E. Sanij, G. Poortinga, R. D. Hannan, K. M. Hannan, , R. B. Pearson

The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.

bioRxiv · Mar 26, 2020Cancer Biology

RNA binding kinase UHMK1 regulates therapy induced metabolic adaptation in BRAFV600 melanoma

L. K. Smith, T. Parmenter, M. Kleinschmidt, E. P. Kusnadi, J. Kang, C. A. Martin, P. Lau, J. Lorent, A. S. Trigos, T. Ward, A. D. Rao, E. J. Lelliott, K. E. Sheppard, D. Goode, R. J. Hicks, , G. A. McArthur

The paper identifies UHMK1 as a regulator of metabolic adaptation in BRAFV600 melanoma under targeted therapy, showing its role in mRNA transport and translation and its impact on therapy resistance.

bioRxiv · Sep 21, 2019Cancer Biology