Author

K. T. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2

Frequent Co-Authors

E. Sanij· 4 shared J. Kang· 4 shared A. S. Trigos· 3 shared C. Cullinane· 3 shared K. M. Hannan· 3 shared R. B. Pearson· 3 shared R. D. Hannan· 3 shared G. A. McArthur· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

E. Sanij

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

J. Kang, R. Pearson, H. Zhu, K. T. Chan, X. Huang, S. Blake, A. S. Trigos, D. Anderson, D. J. S. Creek, D. P. De Souza, X. Wang, C. Fu, M. Jana, E. Sanij

This study shows that Cystathionine-β-synthase (CBS) maintains AKT-induced senescence and suppresses gastric cancer growth in PI3K/AKT-activated cells.

bioRxiv · Jul 4, 2021Cell Biology

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

E. P. Kusnadi, A. S. Trigos, C. Cullinane, D. L. Goode, O. S. Larsson, J. R. Devlin, K. T. Chan, D. P. DeSouza, M. J. McConville, G. A. McArthur, G. Thomas, E. Sanij, G. Poortinga, R. D. Hannan, K. M. Hannan, , R. B. Pearson

The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.

bioRxiv · Mar 26, 2020Cancer Biology

A porcine bimicrobial abscess model for testing interventional treatments

Y.-N. Wang, A. A. Brayman, K. T. Chan, K. Richmond, W. Monsky, T. Matula

This paper develops a porcine bimicrobial abscess model to evaluate interventional treatments for multiloculated abscesses.

bioRxiv · Mar 5, 2020 · PreprintMicrobiology

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

S. Yan, P. B. Madhamshettiwar, K. J. Simpson, S. Ellis, J. Kang, C. Cullinane, K. E. Sheppard, K. M. Hannan, R. D. Hannan, E. Sanij, R. B. Pearson, K. T. Chan

This study identifies that combining RNA Polymerase I inhibitor CX-5461 with TOP1 inhibitor topotecan enhances DNA damage response and efficacy in high-grade serous ovarian cancer.

bioRxiv · Nov 20, 2019Cancer Biology

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

E. Sanij, K. M. Hannan, S. Yan, X. Xuan, J. E. Ahern, K. T. Chan, J. Son, O. Kondrashova, E. Lieschke, M. J. Wakefield, A. S. Trigos, D. Frank, S. Ellis, C. Cullinane, J. Kang, , R. B. Pearson

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.

bioRxiv · Apr 29, 2019 · PreprintCancer Biology