Author

D. P. DeSouza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Assay:clinical cohort / trial· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. S. Trigos· 1 shared C. Cullinane· 1 shared D. L. Goode· 1 shared E. P. Kusnadi· 1 shared E. Sanij· 1 shared G. A. McArthur· 1 shared G. Poortinga· 1 shared G. Thomas· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. S. Trigos

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1 paper

Recent·Most cited

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

E. P. Kusnadi, A. S. Trigos, C. Cullinane, D. L. Goode, O. S. Larsson, J. R. Devlin, K. T. Chan, D. P. DeSouza, M. J. McConville, G. A. McArthur, G. Thomas, E. Sanij, G. Poortinga, R. D. Hannan, K. M. Hannan, , R. B. Pearson

The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.

bioRxiv · Mar 26, 2020Cancer Biology